Sadly this version has some integration issues. Main ones I’ve noticed is not being able to use the “Edit in SharePoint designer” link in the context menu and not being able to edit page layouts in SharePoint Designer.

64-bit Office also has some integration issues. So unless you need 64 bit for working with really large Excel Sheets, I would stick with 32-bit for now.

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Issues with SharePoint Designer 64 bit is a post from: Peter Gerritsen's blog

SharePoint 2010 still uses the same mechanism with an .ACTIONS file and adding an “authorizedType” element to your web.config. I was unsuccessful however in getting the activity to show up in SharePoint Designer 2010.

After adding a “SafeControl” entry to the web.config the activity did show up. As far as I can see this is the only thing different to the steps you have to take in MOSS 2007.

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Getting Custom Workflow Activities into SharePoint Designer 2010 is a post from: Peter Gerritsen's blog